Hardware for Sale
Hitfetcher - Cherry Pick Hits on the Fly
Dynamic HitFetcher from Blackdog Solutions and Hudson Robotics. Eliminate false-positive hits early to save time and compounds.
Easy-to-setup stacker system holds 30
original compound plates, 12 disposable tip boxes, 30
secondary “hit” plates.
- Automatically
cherry pick hits for same day re-testing with no additional effort.
- Handles 96- or
384-well plates and tip boxes without physical setup changes
- Compatible
with any HTS platform - or can be used as a stand alone pipettor for
fluid transfer.
- Finished
“hit” plates can be removed at any time
- Easy-to-load/remove plate
stacks
- Automatic barcode scanning and tracking
- Easy, flexible liquid-handler setup and method development
Same Day Assay Confirmation Using Three Addition Protocol
|
|
Protocol Step |
|
Result Interpretation |
|
1. |
Addition #1 (compound) induces response |
1. |
Compound may be agonist, autofluore, Ca++ ionophore |
|
2. |
Addition
#1 (compound) no response |
2. |
Compound has no activity, (good confirmation test)
|
|
3. |
Addition
#2 (agonist) induces response |
3. |
Compound antagonism not confirmed |
|
4. |
Addition
#2 (agonist) no response |
4. |
Compound antagonism confirmed |
|
5. |
Addition
#3 positive control (Ca++ mobilization) induces response |
5. |
Suggests assay does work & compound antagonism is specific to receptor |
|
6. |
Addition
#3 positive control (Ca++ mobilization) no response |
6. |
Suggests assay failure-compound may be quencher, etc. |
|
